FormulaSeek - Similac ProTotal Comfort vs Enfamil NeuroPro RTF


Updated: 12/7/2024


Introduction

Choosing the right infant formula is crucial for ensuring your baby's optimal growth and development, especially when breastfeeding isn't an option. There are several considerations to bear in mind, such as nutritional content, special dietary needs, and overall formula composition. In this blog post, we will compare two popular infant formulas: Enfamil NeuroPro Ready-to-Feed (RTF) and Similac Pro-Total Comfort, to help you make an informed decision.

Nutritional Composition

Both Enfamil NeuroPro RTF and Similac Pro-Total Comfort offer a blend of nutrients designed to support infant growth, but they differ in specific components:

Enfamil NeuroPro RTF: This formula features a milk-based protein blend, primarily containing a balanced ratio of whey and casein. The main carbohydrate source is lactose. Its fat sources include a mix of palm olein, soy, and coconut oils. Enfamil is fortified with essential vitamins and minerals such as iron and calcium.

Similac Pro-Total Comfort: This formula has partially hydrolyzed protein derived mainly from whey, which makes it easier for babies to digest. Maltodextrin is its primary carbohydrate source, and it uses a blend of safflower and soy oils for fats. It also includes necessary vitamins and minerals for infant health.

Key Differences

Features Enfamil NeuroPro RTF Similac Pro-Total Comfort
Protein Source Whey and Casein Hydrolyzed Whey
Carbohydrate Source Lactose Maltodextrin
Fat Source Palm Olein, Soy, Coconut Oils Safflower, Soy Oils
Prebiotics & Probiotics No No
Omega-3 (DHA/ARA) Levels Included Included
Iron & Calcium Content Iron: 1.8mg, Calcium: 78mg (per 100kcal) Iron: 1.8mg, Calcium: 78mg (per 100kcal)
Estimated Cost per Ounce $0.19 $0.18
Organic/Non-GMO Certification Non-GMO Non-GMO

Note: Prices are estimated and may vary based on location and purchase method.

Special Features and Benefits

Enfamil NeuroPro RTF is noted for its inclusion of MFGM and DHA, nutrients found in breast milk that are associated with brain development. Similac Pro-Total Comfort, on the other hand, uses partially hydrolyzed proteins, which may be easier for babies with sensitive stomachs to digest. Additionally, it contains 2’-FL HMO, a prebiotic that supports a healthy immune system, closely resembling that found in breast milk.

Target Audience

Enfamil NeuroPro RTF is ideal for parents looking for a formula that supports brain development via MFGM and DHA. It’s suitable for babies who tolerate standard lactose-based formulas. Similac Pro-Total Comfort is particularly beneficial for babies with lactose sensitivity or those experiencing fussiness and gas due to its easier-to-digest proteins.

Alternatives to Enfamil NeuroPro RTF

  • Enfamil Enspire
  • Gerber Good Start SoothePro
  • Similac 360 Total Care
  • Happy Baby Organic Infant Formula
  • Earth's Best Organic Infant Formula

Alternatives to Similac Pro-Total Comfort

  • Similac Sensitive
  • Gerber Good Start GentlePro
  • Enfamil Gentlease
  • Earth's Best Organic Gentle Formula
  • Comforts Infant Formula for Fussiness and Gas

Potential Drawbacks

Both formulas have their concerns. Enfamil NeuroPro RTF may be more expensive than powdered formulas, and not all parents prefer formulas containing palm olein oil due to potential digestive issues. Similac Pro-Total Comfort, while designed for sensitive stomachs, might not be suitable for babies severely allergic to cow's milk protein. Availability could also be an issue depending on your location.

Conclusion

Both Enfamil NeuroPro RTF and Similac Pro-Total Comfort are excellent in their own right, catering to different needs. Enfamil is beneficial for supporting cognitive development, while Similac offers relief for sensitive stomachs and similar benefits to breast milk in terms of immune support. Always consult with a pediatrician before transitioning to any formula to ensure it meets your baby's nutritional and health requirements.

Sources*

Buy Similac ProTotal Comfort Online

Buy Enfamil NeuroPro RTF Online

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Nutrient comparison

Similac ProTotal Comfort +/- Data +/- Enfamil NeuroPro RTF
5.40 g 3.30 Fat 2.10 g
10.70 g Carbohydrate 0.60 11.30 g
2.32 g 0.22 Protein 2.10 g
1000.00 mg 220.00 Linoleic Acid 780.00 mg

Minerals comparison

Items in the left column are unique to that formula, same for the right. Items in the middle are in both.

Similac ProTotal Comfort +/- Minerals +/- Enfamil NeuroPro RTF
105.00 mg 27.00 Calcium -27.00 78.00 mg
75.00 mg 33.00 Phosphorus -33.00 42.00 mg
6.00 mg -2.00 Magnesium 2.00 8.00 mg
1.80 mg 0.00 Iron 0.00 1.80 mg
0.75 mg -0.25 Zinc 0.25 1.00 mg
5.00 mcg -10.00 Manganese 10.00 15.00 mcg
90.00 mcg 15.00 Copper -15.00 75.00 mcg
15.00 mcg 0.00 Iodine 0.00 15.00 mcg
2.00 mcg -0.80 Selenium 0.80 2.80 mcg
44.00 mg 17.00 Sodium -17.00 27.00 mg
118.00 mg 10.00 Potassium -10.00 108.00 mg
65.00 mg 2.00 Chloride -2.00 63.00 mg

Vitamins comparison

Vitamins from both formulas are listed in the center. If they exist in a formula they will have a value next to them. The difference will be show under the +/- column for easy visibility.

Similac ProTotal Comfort +/- Vitamin +/- Enfamil NeuroPro RTF
1.50 IU -0.50 Vitamin E 0.50 2.00 IU
8.00 mcg -1.00 Vitamin K 1.00 9.00 mcg
100.00 mcg 20.00 Thiamin (Vit B1) -20.00 80.00 mcg
150.00 mcg 10.00 Riboflavin (Vit B2) -10.00 140.00 mcg
60.00 mcg 0.00 Vitamin B6 0.00 60.00 mcg
0.25 mcg -0.05 Vitamin B12 0.05 0.30 mcg
1050.00 mcg 50.00 Niacin -50.00 1000.00 mcg
15.00 mcg -1.00 Folic Acid 1.00 16.00 mcg
450.00 mcg -50.00 Pantothenic Acid 50.00 500.00 mcg
4.40 mcg 1.40 Biotin -1.40 3.00 mcg
9.00 mg -3.00 Vitamin C 3.00 12.00 mg
24.00 mg 0.00 Choline 0.00 24.00 mg
24.00 mg 0.00 Inositol 0.00 24.00 mg
300.00 IU 0.00 Vitamin A 0.00 300.00 IU
60.00 IU -10.00 Vitamin D 10.00 70.00 IU