FormulaSeek - Enfamil Enspire vs Similac Advance RTF


Updated: 12/7/2024


Introduction

Choosing the right infant formula is an essential decision for parents who are unable to breastfeed or need to supplement breastfeeding. With numerous options available, it's vital to select a formula that meets your infant's nutritional needs and any specific health considerations. Among the various choices, Similac Advance RTF and Enfamil Enspire stand out for their unique formulations. Similac Advance is a ready-to-feed (RTF) formula, while Enfamil Enspire is renowned for its Closest to Breast Milk promise.

Nutritional Composition

When comparing infant formulas, understanding their nutritional components is crucial. Similac Advance RTF and Enfamil Enspire have distinct nutritional profiles:

  • Protein: Similac Advance contains a blend of nonfat milk and whey protein concentrate, whereas Enfamil Enspire utilizes nonfat milk and whey protein as primary protein sources.
  • Carbohydrates: Similac Advance mainly uses lactose as its carbohydrate source; Enfamil Enspire relies on lactose as well.
  • Fat: The fat in Similac Advance comes from a mix of high oleic safflower oil, soy oil, and coconut oil. Enfamil Enspire includes a blend of palm olein, soy, coconut, and high oleic sunflower oil.
  • Vitamins and Minerals: Both formulas are fortified with essential vitamins and minerals, but specific levels may vary slightly between the two.

Key Differences

Feature Similac Advance RTF Enfamil Enspire
Protein Source Nonfat milk, whey protein concentrate Nonfat milk, whey protein
Carbohydrate Source Lactose Lactose
Fat Source High oleic safflower, soy, and coconut oil Palm olein, soy, coconut, high oleic sunflower oil
Prebiotics and Probiotics 2' FL HMO (human milk oligosaccharide) Lactoferrin, MFGM (milk fat globule membrane)
Omega-3 (DHA/ARA) Levels Included Included with proven levels
Iron and Calcium Content Standard levels Standard levels
Estimated Cost per Ounce $0.22 (estimated) $0.25 (estimated)
Organic or Non-GMO Non-GMO Non-GMO

Special Features and Benefits

Similac Advance RTF is known for its inclusion of 2' FL HMO, an important prebiotic initially found in breast milk, known for promoting digestive health and immune support. On the other hand, Enfamil Enspire is notable for its inclusion of lactoferrin and MFGM, compounds present in breast milk that contribute to immune and cognitive development in infants.

Target Audience

Similac Advance RTF may be more suited for babies who benefit from prebiotics for gut health, especially those prone to digestive issues. On the other hand, Enfamil Enspire is ideal for parents seeking a formula with enhanced nutrients closely resembling those found in breast milk, potentially benefiting cognitive development.

Alternatives to Similac Advance RTF

1. Similac Pro-Advance

2. Gerber Good Start Gentle

3. Earth’s Best Organic Dairy Infant Formula

4. Happy Baby Organic Infant Formula

5. Similac Organic with A2 Milk

Alternatives to Enfamil Enspire

1. Enfamil NeuroPro

2. Earth's Best Organic Gentle Infant Formula

3. Plum Organics Grow Well Organic Infant Formula

4. Baby's Only Organic Dairy Formula

5. Gerber Good Start GentlePro

Potential Drawbacks

Similac Advance RTF:

  • Cost: Slightly more expensive due to ready-to-feed convenience.
  • Availability: May not always be in stock, requiring planning ahead.

Enfamil Enspire:

  • Cost: Generally more expensive due to its specialized nutrients.
  • Allergies: Contains milk proteins, so not suitable for infants with milk allergies.

Conclusion

In summary, both Similac Advance RTF and Enfamil Enspire offer unique benefits tailored to different needs. Similac Advance is ideal for infants requiring digestive support and parents who appreciate the convenience of a ready-to-feed option. Enfamil Enspire is beneficial for parents looking for a formula closely resembling breast milk in terms of nutrients essential for brain development. Ultimately, it's important to consider your baby's specific needs and consult with a pediatrician to ensure the best choice for your child.

Sources*

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Buy Similac Advance RTF Online

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Nutrient comparison

Enfamil Enspire +/- Data +/- Similac Advance RTF
5.30 g Fat 0.10 5.40 g
11.10 g Carbohydrate 0.10 11.20 g
2.10 g 0.03 Protein 2.07 g
780.00 mg 780.00 Linoleic Acid 0

Minerals comparison

Items in the left column are unique to that formula, same for the right. Items in the middle are in both.

Enfamil Enspire +/- Minerals +/- Similac Advance RTF
78.00 mg 0.00 Calcium 0.00 78.00 mg
43.00 mg 1.00 Phosphorus -1.00 42.00 mg
8.00 mg 2.00 Magnesium -2.00 6.00 mg
1.80 mg 0.00 Iron 0.00 1.80 mg
1.00 mg 0.25 Zinc -0.25 0.75 mg
15.00 mcg 10.00 Manganese -10.00 5.00 mcg
75.00 mcg -15.00 Copper 15.00 90.00 mcg
15.00 mcg 0.00 Iodine 0.00 15.00 mcg
2.80 mcg 0.80 Selenium -0.80 2.00 mcg
27.00 mg 3.00 Sodium -3.00 24.00 mg
108.00 mg 3.00 Potassium -3.00 105.00 mg
63.00 mg -2.00 Chloride 2.00 65.00 mg

Vitamins comparison

Vitamins from both formulas are listed in the center. If they exist in a formula they will have a value next to them. The difference will be show under the +/- column for easy visibility.

Enfamil Enspire +/- Vitamin +/- Similac Advance RTF
300.00 IU 0.00 Vitamin A 0.00 300.00 IU
70.00 IU 10.00 Vitamin D -10.00 60.00 IU
2.00 IU 0.50 Vitamin E -0.50 1.50 IU
9.00 mcg 1.00 Vitamin K -1.00 8.00 mcg
80.00 mcg -20.00 Thiamin (Vit B1) 20.00 100.00 mcg
140.00 mcg -10.00 Riboflavin (Vit B2) 10.00 150.00 mcg
60.00 mcg 0.00 Vitamin B6 0.00 60.00 mcg
0.30 mcg 0.05 Vitamin B12 -0.05 0.25 mcg
1000.00 mcg -50.00 Niacin 50.00 1050.00 mcg
16.00 mcg 1.00 Folic Acid -1.00 15.00 mcg
500.00 mcg 50.00 Pantothenic Acid -50.00 450.00 mcg
3.00 mcg -1.40 Biotin 1.40 4.40 mcg
12.00 mg 3.00 Vitamin C -3.00 9.00 mg
24.00 mg 0.00 Choline 0.00 24.00 mg
24.00 mg 0.00 Inositol 0.00 24.00 mg